The N-CoR Deacetylase Complex: A Potential Drug Target for Cancer and Other Diseases

Target Name: N-CoR deacetylase complex

NCBI ID: P19041

N-CoR deacetylase complex

Other Name(s): Kaiso-NCOR complex | NCoR deacetylase complex

The N-CoR Deacetylase Complex: A Potential Drug Target for Cancer and Other Diseases

The N-CoR deacetylase complex (Kaiso-NCOR complex) is a protein complex that is involved in the detoxification of harmful substances in the body, particularly those that are metabolized by the liver. The Kaiso-NCOR complex is composed of multiple proteins that work together to remove the acetyl groups from specific target proteins, which allows the proteins to function properly and prevent the buildup of harmful metabolites.

The N-CoR deacetylase complex is a critical pathway for the detoxification of drugs and other harmful substances that are ingested or applied to the skin. Many drugs and other substances have been shown to induce oxidative stress in the liver, leading to the formation of reactive oxygen species (ROS) that can cause damage to the liver cells. The N-CoR deacetylase complex helps to neutralize these ROS by removing the acetyl groups from the target proteins, which reduces the formation of ROS and protects the liver cells.

The Kaiso-NCOR complex is also involved in the detoxification of other harmful substances, such as environmental toxins and certain metabolic waste products. Many of these substances can cause chronic inflammation in the body, leading to the development of diseases such as cancer, autoimmune disorders, and neurodegenerative diseases. The N-CoR deacetylase complex helps to remove these harmful substances from the body and prevent their buildup, which can help to reduce the risk of disease.

The N-CoR deacetylase complex is composed of multiple proteins that work together to remove the acetyl groups from specific target proteins. These proteins include the N-CoR1, N-CoR2, N-CoR3, N-CoR4, and N-CoR5 proteins, which are encoded by the NCR1, NCR2, NCR3, NCR4, and NCR5 genes, respectively. The Kaiso-NCOR complex also includes several non-protein components, such as the Kaiso protein and the NCOR protein.

The N-CoR deacetylase complex is located in the nuclei of the cells, where it is involved in the detoxification of a wide variety of harmful substances. It is also involved in the regulation of cellular processes, such as cell growth, apoptosis, and transcriptional regulation.

The N-CoR deacetylase complex has been shown to be a drug target (or biomarker) for several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. For example, studies have shown that inhibiting the activity of the N-CoR deacetylase complex can lead to the regression of cancer tumors and improve the survival rates of neurodegenerative diseases. In addition, the N-CoR deacetylase complex has been shown to be involved in the development and progression of autoimmune disorders, which may be caused by the formation of ROS that activate and damage immune cells.

The N-CoR deacetylase complex is also a potential biomarker for several diseases, including cancer and neurodegenerative diseases. For example, the N-CoR deacetylase complex has been shown to be overexpressed in the brains of patients with Alzheimer's disease, which is thought to contribute to the development and progression of this disease. In addition, the N-CoR deacetylase complex has been shown to be involved in the development and progression of other neurodegenerative diseases, such as Parkinson's disease and Huntington's disease.

In conclusion, the N-CoR deacetylase complex (Kaiso-NCOR complex) is a protein complex that is involved in the detoxification of harmful substances in the body, particularly those that are metabolized by the liver. It is composed of multiple proteins that work together to remove the acetyl groups from specific target proteins, which helps to reduce the formation of reactive oxygen species (ROS) and protect the liver cells from damage. The N-CoR deacetylase complex is a potential drug target (

Protein Name: N-CoR Deacetylase Complex

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